| Expression pattern: |
UP |
| Associated gene: |
DHX9, PCMT1 mRNA |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, invasion, migration and metastasis of NPC cells; enhances cytoskeletal functions |
| Molecular mechanism: |
acts as a molecular scaffold to facilitate DHX9 binding to PCMT1 mRNA, enabling DHX9 to unwind inhibitory rG4 near translation initiation site and enhance PCMT1 translation |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cytoskeleton polymerization (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; ISH (In Situ Hybridization); RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Sanger Sequencing; RNA Pull-Down; RIP (RNA Immunoprecipitation); circRIP; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
High circCLASP2 expression is associated with poor prognosis in NPC patients; potential biomarker for adjunct diagnosis and prognosis assessment |
| Description: |
circCLASP2 is up-regulated in nasopharyngeal carcinoma and promotes proliferation and metastasis. It functions as a scaffold that increases DHX9 association with PCMT1 mRNA, enabling DHX9 to unwind an inhibitory rG4 near the translation start site and thereby enhance PCMT1 translation, strengthening cytoskeletal dynamics and driving malignancy. |
| Confidence score: |
0.8468 |