circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: CircPVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004992
MONDO name: cancer
Disease details: cancer
Disease DO ID:
 0050686, 0050687, 162
Disease MeSH ID:
 -
Disease NCIt ID:
 C9305
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human MB tumors
Cell lines:

COLO-320DM; SK-PN-DW; D458; U2OS; BxPC-3; DU145
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: AUF1 (HNRNPD)
Associated microRNA: -
Biological function: Promotes cellular proliferation and supports MYC activity; augments AKT signaling and promotes mTORC1 signaling in MYC+ cancer cells.
Molecular mechanism: CircPVT1 encodes the peptide Firefox (FFX); FFX interacts with AUF1 to mediate activation of AKT phosphorylation, leading to enhanced mTORC1 signaling and MYC activity.
Biological pathway or process:

proliferation (promotes); PI3K/AKT (promotes); PI3K/AKT/mTOR (promotes)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Transfection; RNA-seq; Bioinformatics Analysis; Co-IP; Western Blot; CCK8; In Vivo Animal Model
Clinical significance:

-
Description:

CircPVT1 is enriched in MYC/PVT1-rearranged MYC+ cancer cell lines and encodes the peptide Firefox (FFX). FFX promotes proliferation and enhances MYC and mTORC1 activity by activating AKT signaling, at least in part via interaction with AUF1.
Confidence score:

0.6683
Other information
Title:

Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.

Journal: bioRxiv : the preprint server for biology
Published: 2025
PubMed ID: 40027648
Study type:

combined biological and clinical study
Data availability: -
Code availability: -