| Expression pattern: |
UP |
| Associated gene: |
PTEN, p-p65, p65 |
| Associated microRNA: |
miR-337-3p |
| Biological function: |
circRNA_0092516 knockdown boosted chondrocyte proliferation, restrained apoptosis, reduced OA-related inflammatory factors and cartilage-degradation markers, and repaired articular cartilage injury in vivo. |
| Molecular mechanism: |
circRNA_0092516 acts as a ceRNA sponge for miR-337-3p, negatively regulates miR-337-3p, and affects PTEN expression and the NF-kappaB signaling pathway. |
| Biological pathway or process: |
ceRNA regulation (promotes); NF-kappaB (promotes); proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
This might provide new strategies and directions for the cure of OA. |
| Description: |
circRNA_0092516 is up-regulated in OA cartilage tissues and IL-1beta-stimulated chondrocytes. Its knockdown alleviates OA-related phenotypes by promoting chondrocyte proliferation, inhibiting apoptosis and inflammatory mediator release, and regulating the miR-337-3p/PTEN axis with effects on NF-kappaB signaling. |
| Confidence score: |
0.7045 |