circRNA basic information
circBase ID: hsa_circ_0001421
Name: -
Synonym: circRNA_0001421 / circ_0001421
Host Gene: -
Genomic location(hg19): chr4:83799882-83803090:-
Genomic location(hg38): chr4:82878729-82881937:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; normal peritumor tissues
Cell lines:

H1975; A549; BEAS-2B
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TMEM14A
Associated microRNA: miR-409-3p
Biological function: Promotes colony formation, migration, invasion and glycolysis; promotes tumor growth in vivo
Molecular mechanism: ceRNA sponge mechanism: circ_0001421 sponges miR-409-3p to upregulate TMEM14A
Biological pathway or process:

glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model
Clinical significance:

Circ_0001421 may be a promising therapeutic target in NSCLC.
Description:

circ_0001421 is up-regulated in NSCLC tissues and cell lines and mainly localizes in the cytoplasm. Functionally, circ_0001421 promotes NSCLC colony formation, migration, invasion, glycolysis, and tumor growth in vivo by sponging miR-409-3p to increase TMEM14A expression.
Confidence score:

0.6578
Other information
Title:

Circular RNA circ_0001421 contributes to colony formation, migration, invasion and glycolysis of non-small cell lung cancer via the miR-409-3p/TMEM14A axis.

Journal: Archives of medical science : AMS
Published: 2025
PubMed ID: 41684556
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -