| Expression pattern: |
UP |
| Associated gene: |
CREB5 |
| Associated microRNA: |
miR-556-5p |
| Biological function: |
CircMAP2K2 promotes GC cell viability, growth, migration, and invasion; circMAP2K2 depletion hinders GC cell growth, migration, and invasion. |
| Molecular mechanism: |
CircMAP2K2 acts as a ceRNA by sponging miR-556-5p and upregulates CREB5 expression, thereby promoting GC development. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Survival Analysis; Bioinformatics Analysis; Microarray |
| Clinical significance: |
High circMAP2K2 expression is associated with lower survival rate in GC patients; diagnostic and prognostic values of circRNA circMAP2K2 in GC were identified. |
| Description: |
CircMAP2K2 is upregulated in gastric cancer tissues and cell lines and high expression is associated with poorer patient survival. Functionally, circMAP2K2 promotes GC cell viability, proliferation, migration, and invasion. Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-556-5p to increase CREB5 expression, forming an oncogenic circMAP2K2/miR-556-5p/CREB5 axis. |
| Confidence score: |
0.8389 |