| Expression pattern: |
UP |
| Associated gene: |
FGF9, AGO2 |
| Associated microRNA: |
miR-582-5p |
| Biological function: |
promotes gemcitabine resistance; promotes proliferation; promotes migration; promotes DNA damage repair; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponge mechanism: hsa_circ_0125356 sponges miR-582-5p to upregulate FGF9, activating WNT canonical (ERK/GSK3beta/beta-catenin) and non-canonical (Daam1/RhoA/ROCK2) signaling to enhance gemcitabine resistance |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); ERK (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); ceRNA regulation (promotes); drug resistance (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; TUNEL; Western Blot; IHC (Immunohistochemistry); IF (Immunofluorescence); Cell Cycle Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
significantly upregulated in NSCLC cancer tissues and served as a biomarker for gemcitabine resistance; higher expression predicted poorer survival outcomes |
| Description: |
hsa_circ_0125356 is upregulated in NSCLC and promotes gemcitabine resistance. It functions as a ceRNA by sponging miR-582-5p to upregulate FGF9, thereby activating canonical and non-canonical WNT signaling, enhancing DNA damage repair and reducing apoptosis; high expression is associated with poorer survival. |
| Confidence score: |
0.873 |