circRNA basic information
circBase ID: hsa_circ_0001947
Name: hsa_circ_AFF2
Synonym: hsa_circRNA_105034 / circ-AFF2
Host Gene: AFF2
Genomic location(hg19): chrX:147743428-147744289:+
Genomic location(hg38): chrX:148661907-148662768:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009693
MONDO name: plasma cell myeloma
Disease details: multiple myeloma
Disease DO ID:
 9538
Disease MeSH ID:
 D009101
Disease NCIt ID:
 C3242
Disease ICD11 ID:
 1582389689; 526287100
Disease OMIM ID:
 254500
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow plasma cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-638
Biological function: associated with favorable treatment response and survival; may reduce drug resistance
Molecular mechanism: may act as a miRNA sponge (ceRNA) for miR-638
Biological pathway or process:

ceRNA regulation (inhibits); drug resistance (inhibits)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

predicted good treatment response and survival in MM patients
Description:

circ-AFF2 is down-regulated in multiple myeloma and has diagnostic value, while higher circ-AFF2 levels indicate better treatment response and improved survival. It is proposed to act as a ceRNA by sponging miR-638 and potentially reducing drug resistance.
Confidence score:

0.636
Other information
Title:

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.

Journal: BMC cancer
Published: 2020
PubMed ID: 31948430
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -