| Expression pattern: |
UP |
| Associated gene: |
NRP2, Ago2, MMP2, MMP9, ki-67 |
| Associated microRNA: |
miR-1287-5p |
| Biological function: |
Acts as an oncogenic factor in PTC; promotes proliferation, migration, invasion, glycolysis and tumor growth; inhibits apoptosis when expressed. |
| Molecular mechanism: |
circPI4KA sponges miR-1287-5p to elevate NRP2 expression, thereby promoting malignant progression and glycolytic metabolism in PTC. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circPI4KA expression was associated with TNM stage and lymph node metastasis in PTC patients. |
| Description: |
circPI4KA is overexpressed in PTC tissues and cell lines and functions as a pro-cancer circRNA. It promotes PTC cell proliferation, migration, invasion, glycolysis and in vivo tumor growth while suppressing apoptosis, mainly through sponging miR-1287-5p to increase NRP2 expression. Clinically, its expression is associated with TNM stage and lymph node metastasis. |
| Confidence score: |
0.8443 |