circRNA basic information
circBase ID: hsa_circ_0080229
Name: hsa_circ_EGFR
Synonym: circEGFR
Host Gene: EGFR
Genomic location(hg19): chr7:55231425-55233130:+
Genomic location(hg38): chr7:55163732-55165437:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; healthy brain
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: None (this paper reports expression increase as a progression marker; no mechanism experimentally established).
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment
Clinical significance:

progression marker in recurrent GBM
Description:

circEGFR (hsa_circ_0080229) is up-regulated in recurrent GBM compared with primary GBM, with very large fold-change by RT-qPCR, and is proposed as a progression-associated circRNA marker in this dataset; no direct functional mechanism was established in this paper.
Confidence score:

0.3401
Other information
Title:

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.

Journal: Molecular oncology
Published: 2025
PubMed ID: 40008750
Study type:

combined biological and clinical study
Data availability: GSE196695
Code availability: https://github.com/MSajek/GBM_circs