circRNA basic information
circBase ID: -
Name: hsa_circ_VCAN
Synonym: circVCAN
Host Gene: VCAN
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; healthy brain
Cell lines:

U-118 MG; U-251 MG
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FUS
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Binds FUS in GBM cells (validated by CLIP).
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; CLIP; RIP (RNA Immunoprecipitation); Western Blot
Clinical significance:

-
Description:

circVCAN is one of the most up-regulated circRNAs in primary GBM samples and is mainly nuclear. It directly interacts with the RBP FUS as supported by CLIP enrichment, indicating a circRNA/RBP interaction relevant to GBM.
Confidence score:

0.6324
Other information
Title:

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.

Journal: Molecular oncology
Published: 2025
PubMed ID: 40008750
Study type:

combined biological and clinical study
Data availability: GSE196695
Code availability: https://github.com/MSajek/GBM_circs