| Expression pattern: |
DN |
| Associated gene: |
VGLL4 |
| Associated microRNA: |
miR-346 |
| Biological function: |
Suppresses multiplication, migration, invasion and EMT of NSCLC cells. |
| Molecular mechanism: |
Acts as a molecular sponge for miR-346 to enhance VGLL4 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Reduced level of circ_0006427 in NSCLC tissues was associated with larger tumor size and positive lymph node metastasis. |
| Description: |
circ_0006427 is down-regulated in NSCLC tissues/cells and acts as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT. It functions as a ceRNA that sponges miR-346, thereby relieving repression of VGLL4 and suppressing NSCLC progression. |
| Confidence score: |
0.6777 |