circRNA basic information
circBase ID: hsa_circ_0080850
Name: hsa_circ_PTPN12
Synonym: -
Host Gene: PTPN12
Genomic location(hg19): chr7:77236551-77261742:+
Genomic location(hg38): chr7:77607234-77632425:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: In ELN2022 Favorable AML subgroup, high expression is associated with worse survival and reduced complete remission rate after induction treatment.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Within the ELN2022 Favorable subgroup, high expression is associated with worse survival and lower remission rates.
Description:

hsa_circ_0080850 (PTPN12-derived) is a subgroup-specific prognostic marker in ELN2022 Favorable AML: high expression predicts poorer survival and markedly lower complete remission rates after induction therapy, with no corresponding prognostic signal from the host gene.
Confidence score:

0.348
Other information
Title:

Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.

Journal: NPJ precision oncology
Published: 2026
PubMed ID: 41787043
Study type:

combined biological and clinical study
Data availability: phs001657.v1.p1; GSE158596; https://zenodo.org/records/7274740; 10.5281/zenodo.292986
Code availability: -