circRNA basic information
circBase ID: hsa_circ_0008346
Name: hsa_circ_NUSAP1
Synonym: circ_0008346
Host Gene: NUSAP1
Genomic location(hg19): chr15:41648236-41669502:+
Genomic location(hg38): chr15:41356038-41377304:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor tissue; para-carcinoma tissue
Cell lines:

HL-7702; HepG2; Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDC25A, CDCA4, CHEK1
Associated microRNA: miR-242-5p
Biological function: Promotes HCC cell viability and motility (proliferation and migration), as its knockdown reduced viability and motility.
Molecular mechanism: Predicted ceRNA networks mediated by circ_0008346 were not supported by knockdown results (miRNA and hub-gene changes conflicted).
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; CCK8; Wound Healing Assay
Clinical significance:

-
Description:

circ_0008346 is upregulated in HCC and supports HCC cell proliferation/motility, since ASO knockdown reduced viability and motility. The predicted circ_0008346-centered ceRNA networks tested were not validated by miRNA/hub gene expression responses.
Confidence score:

0.4469
Other information
Title:

Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2025
PubMed ID: 40003874
Study type:

combined biological and clinical study
Data availability: GSE216613; GSE125469; GSE128274; GSE169391; GSE122482; TCGA-LIHC
Code availability: -