circRNA basic information
circBase ID: hsa_circ_0000943
Name: -
Synonym: circ_0000943
Host Gene: -
Genomic location(hg19): chr19:47421744-47440665:+
Genomic location(hg38): chr19:46918487-46937408:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor tissue; para-carcinoma tissue
Cell lines:

HL-7702; HepG2; Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: OIP5, KPNA2
Associated microRNA: miR-103a-3p, miR-20b-5p
Biological function: Promotes HCC cell viability and motility (proliferation and migration), as its knockdown reduced viability and motility.
Molecular mechanism: Predicted ceRNA regulation was not validated for circ_0000943 in the tested networks.
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; CCK8; Wound Healing Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

circ_0000943 is upregulated in HCC and its knockdown decreases HCC cell viability and motility. However, the predicted ceRNA network relationships tested for circ_0000943 were not validated in the authors’ assays.
Confidence score:

0.5627
Other information
Title:

Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2025
PubMed ID: 40003874
Study type:

combined biological and clinical study
Data availability: GSE216613; GSE125469; GSE128274; GSE169391; GSE122482; TCGA-LIHC
Code availability: -