| Expression pattern: |
UP |
| Associated gene: |
SLC5A1 |
| Associated microRNA: |
miR-1305, miR-1322 |
| Biological function: |
promotes proliferation; suppresses apoptosis; enhances glycolytic capacity |
| Molecular mechanism: |
May act as a miRNA sponge (ceRNA-like) for miR-1305 and miR-1322 to upregulate SLC5A1. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
High expression of circ_0003028 is associated with poor overall survival and shows high diagnostic potential in NSCLC patients (AUC 0.8724). |
| Description: |
Circ_0003028 is up-regulated in NSCLC tissues and promotes malignant phenotypes by enhancing proliferation and glycolytic capacity while inhibiting apoptosis in NSCLC cells. Mechanistically, it is mainly cytoplasmic and is proposed to sponge miR-1305 and miR-1322 to increase SLC5A1 expression, contributing to increased glycolysis. Clinically, higher circ_0003028 expression is associated with poorer overall survival and shows diagnostic potential. |
| Confidence score: |
0.8135 |