| Expression pattern: |
UP |
| Associated gene: |
Forkhead Box M1 / FOXM1 |
| Associated microRNA: |
- |
| Biological function: |
Regulates and promotes proliferation, invasion, and drug resistance of gastric cancer cells. |
| Molecular mechanism: |
FOXM1-mediated regulation of circ_NOTCH1 expression affects gastric cancer cell proliferation, invasion, and drug resistance. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
- |
| Description: |
This study investigated circ_NOTCH1 in gastric cancer cells. FOXM1 regulates gastric cancer cell proliferation, invasion, and drug resistance through circ_NOTCH1, indicating a FOXM1/circ_NOTCH1 regulatory relationship relevant to malignant cellular behavior and treatment response. |
| Confidence score: |
0.5223 |