| Expression pattern: |
UP |
| Associated gene: |
AGO1, AGO2, EIF4A3, FMRP, HuR (ELAVL1), IGF2BP1, IGF2BP2, IGF2BP3, EWSR1, FUS, PTB |
| Associated microRNA: |
hsa-miR-149, hsa-miR-182, hsa-miR-383 |
| Biological function: |
Predicted hub circRNA acting as a super sponge with multiple miRNA response elements and potential capability of gene expression regulation in breast cancer. |
| Molecular mechanism: |
Predicted ceRNA mechanism through miRNA sponging, with predicted RBP interactions and downstream miRNA-mRNA/PPI network analysis. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
Suggested as a potential targetable therapeutic element for breast cancer. |
| Description: |
hsa_circ_0001955 was identified as an up-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance. |
| Confidence score: |
0.1768 |