circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_101996
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissues; adjacent normal tissues
Cell lines:

SiHa; C33A; CaSki; Hela; HeLa; HCerEpiC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TPX2
Associated microRNA: miR-8075
Biological function: Promotes cervical cancer cell proliferation, cell cycle progression, migration, invasion, and tumor propagation in vivo.
Molecular mechanism: hsa_circRNA_101996 acts as a miR-8075 sponge, relieves miR-8075-mediated repression of TPX2, and thereby increases TPX2 expression to promote cervical cancer progression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; Survival Analysis; Cohort Study
Clinical significance:

High hsa_circRNA_101996 expression is positively correlated with TNM stage, tumor size, and lymph node metastasis, and is associated with poor survival of cervical cancer patients.
Description:

hsa_circRNA_101996 is up-regulated in cervical cancer tissues and cell lines, and high expression is associated with advanced stage, larger tumor size, lymph node metastasis, and poor survival. Functionally, it promotes cervical cancer proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-8075 sponge to increase TPX2 expression, forming a hsa_circRNA_101996-miR-8075-TPX2 regulatory network that promotes cervical cancer progression.
Confidence score:

0.7733
Other information
Title:

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075.

Journal: Journal of cellular physiology
Published: 2019
PubMed ID: 30633364
Study type:

combined biological and clinical study
Data availability: GSE102686
Code availability: -