| Expression pattern: |
UP |
| Associated gene: |
GALNT6, Ago2 |
| Associated microRNA: |
miR-1205 |
| Biological function: |
promotes proliferation and invasion and inhibits apoptosis of breast cancer cells; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a sponge for miR-1205 to regulate GALNT6 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0119412 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. Its knockdown suppresses proliferation/invasion, increases apoptosis, and inhibits xenograft tumor growth by acting as a ceRNA that sponges miR-1205 to relieve repression of GALNT6. |
| Confidence score: |
0.762 |