circRNA basic information
circBase ID: hsa_circ_0007059
Name: hsa_circ_ZNF720
Synonym: circ_0007059
Host Gene: ZNF720
Genomic location(hg19): chr16:31733946-31734674:+
Genomic location(hg38): chr16:31722625-31723353:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; peritumor tissues; HCC tumor tissues
Cell lines:

SK-HEP1; HUH-7; MHCC97H; THLE-2; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN, AKT, mTOR
Associated microRNA: miR-421
Biological function: Circ_0007059 inhibits HCC cell proliferation, migration, invasion and stem cell-like property, and promotes apoptosis.
Molecular mechanism: Circ_0007059 functions as a cytoplasmic miR-421 sponge to upregulate PTEN and suppress AKT/mTOR signaling in HCC cells.
Biological pathway or process:

PI3K/AKT/mTOR (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); stemness (inhibits); ceRNA regulation (other)
Detected method:
Q
B
Validation methods:

RNase R Treatment; RT-qPCR; Northern Blot; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Circ_0007059 may provide a therapeutic strategy or target for HCC.
Description:

Hsa_circ_0007059/circ_0007059 is downregulated in HCC tissues and cells. It acts as a tumor-suppressive circRNA by sponging miR-421, increasing PTEN expression, and suppressing AKT/mTOR signaling, thereby inhibiting proliferation, migration, invasion and stemness while promoting apoptosis in HCC cells.
Confidence score:

0.7893
Other information
Title:

Hsa_circ_0007059 sponges miR-421 to repress cell growth and stemness in hepatocellular carcinoma by the PTEN-AKT/mTOR pathway.

Journal: Pathology, research and practice
Published: 2022
PubMed ID: 34847369
Study type:

combined biological and clinical study
Data availability: TCGA database; UCSC database; CircInteractome database; starBase database
Code availability: -