circRNA basic information
circBase ID: hsa_circ_0003892
Name: hsa_circ_LDLR
Synonym: hsa_circRNA_102451
Host Gene: LDLR
Genomic location(hg19): chr19:11230767-11238761:+
Genomic location(hg38): chr19:11120091-11128085:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; normal liver tissues; matched paracancerous tissues; matched adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-326
Biological function: unknown
Molecular mechanism: ceRNA mechanism (competitive binding/sponging miRNAs) inferred by bioinformatics network construction
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_102451 is upregulated in HCC and predicted to interact with hsa-miR-326 in the computational circRNA-miRNA network. The paper did not link this circRNA to specific downstream mRNA targets, pathways, or clinical outcomes.
Confidence score:

0.1768
Other information
Title:

Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.

Journal: Clinical and experimental medicine
Published: 2025
PubMed ID: 39961942
Study type:

bioinformatics study
Data availability: GSE78520; GSE94508; GSE97332; TCGA LIHC
Code availability: -