| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion |
| Molecular mechanism: |
Bioinformatics prediction of circRNA-miRNA interaction network; specific miRNA/mRNA axis in CRC not experimentally validated in this study. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
circDOCK1 exhibited elevated expression in patients with CRC and emerged as an independent prognostic factor; high circDOCK1 expression is an unfavorable prognostic factor in patients with CRC. |
| Description: |
In colorectal cancer, circDOCK1 is up-regulated in tumor tissues and functions as an oncogenic circRNA that promotes CRC cell proliferation, migration, and invasion. Clinically, higher circDOCK1 expression is associated with worse overall survival and is reported as an independent prognostic risk factor. |
| Confidence score: |
0.7041 |