| Expression pattern: |
UP |
| Associated gene: |
IFIT1, IFIT3 |
| Associated microRNA: |
hsa-miR-127-5p |
| Biological function: |
diagnostic biomarker for AIS; potential monitoring marker for AIS progression/dynamics |
| Molecular mechanism: |
predicted ceRNA network: hsa_circ_0000994-hsa-miR-127-5p-IFIT1/IFIT3 |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Circulating circSLC8A1 is upregulated in AIS and shows diagnostic value (ROC AUC 0.853) to distinguish AIS patients from healthy controls; longitudinally remains elevated at later time points suggesting potential for monitoring. |
| Description: |
circSLC8A1 (hsa_circ_0000994) is upregulated in AIS patient plasma and has diagnostic utility by ROC/logistic regression, with longitudinal changes suggesting monitoring potential. It is predicted to participate in a ceRNA axis involving hsa-miR-127-5p and the immune-related hub genes IFIT1/IFIT3. |
| Confidence score: |
0.5849 |