| Expression pattern: |
DN |
| Associated gene: |
AKT, mTOR |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation and migration; alleviates malignant development; linked to metastasis |
| Molecular mechanism: |
inactivates (negatively regulates) AKT/mTOR signaling and downregulates AKT and mTOR |
| Biological pathway or process: |
PI3K/AKT/mTOR (inhibits); proliferation (inhibits); migration (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
A low level of circNR3C1 predicted high incidences of lymphatic or distant metastasis of GC. |
| Description: |
circNR3C1 is down-regulated in gastric cancer tissues/cells and functions as a tumor suppressor by inhibiting GC cell proliferation and migration. Mechanistically, it inactivates the AKT/mTOR signaling pathway by reducing AKT and mTOR levels, and low circNR3C1 expression is associated with lymphatic/distant metastasis. |
| Confidence score: |
0.5358 |