circRNA basic information
circBase ID: hsa_circ_0006620
Name: hsa_circ_ITM2B
Synonym: circItm2b
Host Gene: ITM2B
Genomic location(hg19): chr13:48827943-48835457:+
Genomic location(hg38): chr13:48253807-48261321:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0858950
MONDO name: traumatic brain injury
Disease details: traumatic brain injury / TBI
Disease DO ID:
 0081292
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; contused brain tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Acts as a biomarker associated with sleep disturbance severity and EEG sleep architecture changes after TBI.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Up-regulated in TBI patient serum and contused brain tissue; positively correlated with PSQI and AIS scores; ROC AUC=0.7657 for diagnosing sleep disorders after TBI; negatively correlated with delta wave energy density in moderate TBI group.
Description:

hsa_circ_0006620 is significantly up-regulated in serum (and elevated in contused brain tissue) of acute TBI patients and is associated with post-TBI sleep disturbance severity, showing positive correlations with PSQI/AIS and diagnostic value by ROC analysis.
Confidence score:

0.4187
Other information
Title:

CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury.

Journal: Cell & bioscience
Published: 2025
PubMed ID: 39962534
Study type:

clinical study
Data availability: -
Code availability: -