circRNA basic information
circBase ID: hsa_circ_0001900
Name: hsa_circ_CAMSAP1
Synonym: hsa_circRNA_000996
Host Gene: CAMSAP1
Genomic location(hg19): chr9:138773478-138774924:-
Genomic location(hg38): chr9:135881632-135883078:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; normal liver tissues; matched paracancerous tissues; matched adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F1
Associated microRNA: hsa-miR-370-3p, hsa-miR-136-5p
Biological function: promotes tumour growth and advancement (inferred via hub-gene-centered ceRNA network)
Molecular mechanism: ceRNA axis: hsa-circ-000996 sponges hsa-miR-136-5p to enhance E2F1 in the final network
Biological pathway or process:

ceRNA regulation (promotes); cell cycle (promotes); angiogenesis (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

This circRNA was among upstream circRNAs of the final hub-gene network; hub genes/modules were associated with pathological stage, survival, and B-cell infiltration (circRNA implication is indirect).
Description:

hsa_circRNA_000996 is upregulated in HCC and included in the final ceRNA network as part of the miR-136-5p/E2F1 axis (with other circRNAs). It is indirectly implicated in HCC progression via ceRNA-mediated regulation of the hub gene E2F1.
Confidence score:

0.1768
Other information
Title:

Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.

Journal: Clinical and experimental medicine
Published: 2025
PubMed ID: 39961942
Study type:

bioinformatics study
Data availability: GSE78520; GSE94508; GSE97332; TCGA LIHC
Code availability: -