circRNA basic information
circBase ID: hsa_circ_0069094
Name: hsa_circ_S100P
Synonym: circ_0069094
Host Gene: -
Genomic location(hg19): chr4:6698619-6698897:+
Genomic location(hg38): chr4:6696892-6697170:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues; breast cancer tumor tissues; normal tissues; plasma
Cell lines:

MDA-MB-231; BT-549; MCF-10A; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ZNF217
Associated microRNA: miR-758-3p
Biological function: Hsa_circ_0069094 acts as an oncogenic circRNA in breast cancer; its knockdown inhibits cell proliferation, invasion, migration, cell cycle progression and xenograft tumor growth, and promotes apoptosis.
Molecular mechanism: ceRNA mechanism: hsa_circ_0069094 competitively binds miR-758-3p and thereby positively regulates the oncogenic target ZNF217.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

-
Description:

Hsa_circ_0069094 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, invasion, migration, cell cycle progression and tumor growth while inhibiting apoptosis, mainly through a ceRNA mechanism involving miR-758-3p and ZNF217.
Confidence score:

0.8006
Other information
Title:

Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.

Journal: Reproductive biology
Published: 2022
PubMed ID: 36356557
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request; doi:10.1016/j.repbio.2022.100708
Code availability: -