| Expression pattern: |
UP |
| Associated gene: |
KIF2A, Ago2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Promotes NSCLC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumour growth and metastasis/EMT-like changes. |
| Molecular mechanism: |
circ_0010235 acts as a ceRNA by sponging miR-338-3p, thereby relieving repression of KIF2A. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0010235 is upregulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration/invasion and tumour growth while promoting apoptosis, mainly via the circ_0010235-miR-338-3p-KIF2A ceRNA axis and associated EMT marker changes (E-cadherin/N-cadherin). |
| Confidence score: |
0.7983 |