circRNA basic information
circBase ID: hsa_circ_0001451
Name: hsa_circ_FBXW7
Synonym: circFBXW7
Host Gene: FBXW7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissue; adjacent normal lung tissues
Cell lines:

BEAS-2B; A549; HCC2279; H1299
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: BARX2, AGO2
Associated microRNA: miR-942-5p
Biological function: inhibits proliferation and migration; suppresses tumor growth; inhibits EMT
Molecular mechanism: acts as a miRNA sponge (ceRNA) for miR-942-5p to upregulate BARX2, affecting EMT markers
Biological pathway or process:

proliferation (inhibits); migration (inhibits); EMT (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

LUAD patients with low expression levels of circFBXW7 had shorter DFS and OS; circFBXW7 may be a prognostic biomarker
Description:

In LUAD, circFBXW7 is down-regulated and functions as a tumor suppressor by inhibiting proliferation, migration, tumor growth, and EMT. Mechanistically, it sponges miR-942-5p to relieve repression of BARX2 (circFBXW7/miR-942-5p/BARX2 axis), and low circFBXW7 expression is associated with shorter DFS/OS.
Confidence score:

0.8308
Other information
Title:

circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.

Journal: Translational lung cancer research
Published: 2021
PubMed ID: 33889522
Study type:

combined biological and clinical study
Data availability: http://dx.doi.org/10.21037/tlcr-21-230
Code availability: -