| Expression pattern: |
UP |
| Associated gene: |
RAD51 |
| Associated microRNA: |
hsa-miR-758-3p |
| Biological function: |
promotes tumour growth and advancement (inferred via hub-gene-centered ceRNA network) |
| Molecular mechanism: |
ceRNA axis: hsa-circ-104760 sponges hsa-miR-758-3p to enhance RAD51 in the final network |
| Biological pathway or process: |
ceRNA regulation (promotes); cell cycle (promotes); angiogenesis (promotes) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis |
| Clinical significance: |
This circRNA was included among upstream circRNAs of the final hub-gene network; the associated hub genes/modules were linked to pathological stage, survival, and B-cell infiltration (circRNA implication is indirect). |
| Description: |
hsa_circRNA_104760 is upregulated in HCC and was placed in the final ceRNA network as the upstream circRNA of the miR-758-3p/RAD51 axis. It is therefore implicated in promoting HCC progression through ceRNA-mediated upregulation of the hub gene RAD51. |
| Confidence score: |
0.1768 |