| Expression pattern: |
UP |
| Associated gene: |
HMGA1 |
| Associated microRNA: |
miR-16-5p |
| Biological function: |
promotes paclitaxel resistance, migration and invasion, and inhibits apoptosis in Tax-resistant gastric cancer cells; its knockdown sensitizes cells/tumors to paclitaxel and suppresses malignant progression |
| Molecular mechanism: |
ceRNA mechanism: circ_002136 sponges miR-16-5p to release HMGA1 repression, promoting paclitaxel resistance and invasion |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
higher circ_002136 expression correlates with paclitaxel (Tax) resistance/sensitivity in gastric cancer patients |
| Description: |
circ_002136 (hsa_circ_002136) is upregulated in gastric cancer, especially in paclitaxel-resistant tissues/cells. It promotes paclitaxel resistance and invasive behaviors by sponging miR-16-5p to derepress HMGA1; silencing circ_002136 increases paclitaxel sensitivity, inhibits migration/invasion, and induces apoptosis in vitro and suppresses xenograft growth in vivo. |
| Confidence score: |
0.8442 |