| Expression pattern: |
UP |
| Associated gene: |
Wnt/beta-catenin pathway, pGSK3beta/GSK3beta, Nucleus beta-catenin, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-411, miR-1205 |
| Biological function: |
Promotes CRC cell proliferation, cell cycle progression, migration/invasion/metastasis and EMT; inhibits apoptosis; accelerates tumorigenesis in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA-like) for miR-411 and miR-1205, leading to activation of Wnt/beta-catenin signaling and promotion of EMT. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); EMT (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_0082182 expression predicts poor overall survival in CRC patients; associated with TNM stage and lymph node metastasis. |
| Description: |
circ_0082182 is up-regulated in colorectal cancer and its high expression is associated with worse overall survival. It promotes proliferation, cell-cycle progression, migration/invasion, EMT and tumor growth by sponging miR-411 and miR-1205 to activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.7372 |