circRNA basic information
circBase ID: hsa_circ_0032698
Name: hsa_circ_TTLL5
Synonym: hsa_circRNA_101408
Host Gene: TTLL5
Genomic location(hg19): chr14:76135758-76368567:+
Genomic location(hg38): chr14:75669415-75902224:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; normal liver tissues; matched paracancerous tissues; matched adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: E2F1, H2AFX, TOP2A
Associated microRNA: hsa-miR-370-3p, hsa-miR-136-5p, hsa-miR-145-5p, hsa-miR-383-5p, hsa-miR-374-3p, hsa-miR-375
Biological function: promotes tumour growth and advancement (inferred via hub-gene-centered ceRNA network)
Molecular mechanism: ceRNA network: sponging miRNAs (hsa-miR-136-5p, hsa-miR-145-5p, hsa-miR-383-5p) to enhance hub-gene mRNAs (E2F1, H2AFX, TOP2A)
Biological pathway or process:

ceRNA regulation (promotes); cell cycle (promotes); angiogenesis (promotes)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

The DUcircRNA-regulated hub genes/modules were closely associated with pathological stage, patient survival, and B-cell immune infiltration (circRNA implication is indirect).
Description:

hsa_circRNA_101408 is upregulated in HCC and forms multiple predicted ceRNA axes, including miR-136-5p/E2F1, miR-145-5p/H2AFX, and miR-383-5p/TOP2A. Through these axes it is implicated in promoting HCC progression, with downstream hub genes enriched in cell-cycle and angiogenesis-related processes.
Confidence score:

0.1768
Other information
Title:

Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.

Journal: Clinical and experimental medicine
Published: 2025
PubMed ID: 39961942
Study type:

bioinformatics study
Data availability: GSE78520; GSE94508; GSE97332; TCGA LIHC
Code availability: -