| Expression pattern: |
UP |
| Associated gene: |
c-Myc |
| Associated microRNA: |
miR-150-5p |
| Biological function: |
Promotes GC cell proliferation, tumourigenicity, migration, invasion, and metastasis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-150-5p and indirectly regulates c-Myc expression (ceRNA-like regulation). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; circRIP; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circLMTK2 expression was associated with poor prognosis, lymph node metastasis and poor TNM stage in GC patients; circLMTK2 level was an independent prognostic factor for OS. |
| Description: |
circLMTK2 (hsa_circ_0001725), derived from LMTK2, is up-regulated in gastric cancer and mainly localizes to the cytoplasm. It promotes proliferation, tumourigenicity, migration/invasion and metastasis by sponging miR-150-5p to increase c-Myc expression, and high circLMTK2 predicts poor overall survival. |
| Confidence score: |
0.8837 |