| Expression pattern: |
UP |
| Associated gene: |
Caprin1 |
| Associated microRNA: |
- |
| Biological function: |
promotes HCC cell proliferation and regulates cell cycle; knockdown represses cell growth and increases the percentage of G0/G1 cells |
| Molecular mechanism: |
circ_0000885 promotes HCC tumorigenesis by upregulating Caprin1 expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Western Blot |
| Clinical significance: |
high circ_0000885 expression was associated with lymphatic metastasis and advanced TNM stage; circ_0000885 could indicate the clinical outcomes of HCC |
| Description: |
circ_0000885 is up-regulated in HCC tissues and HCC cell lines. Its high expression is associated with lymphatic metastasis and advanced TNM stage, and functional knockdown experiments indicate that it promotes HCC cell proliferation and cell-cycle progression, at least partly by upregulating Caprin1. |
| Confidence score: |
0.5414 |