| Expression pattern: |
UP |
| Associated gene: |
LEF1, Ago2 |
| Associated microRNA: |
miR-498 |
| Biological function: |
promotes migration and proliferation; suppresses apoptosis; promotes malignancy/tumorigenesis of osteosarcoma cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0032463 sponges miR-498 to enhance LEF1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Wound Healing Assay; Annexin V/PI Flow Cytometry; Microarray |
| Clinical significance: |
circ_0032463 should be considered a novel biomarker for treating and diagnosing OS. |
| Description: |
In osteosarcoma, circ_0032463 (hsa_circ_0032463) is upregulated and mainly localized in the cytoplasm. It promotes proliferation and migration and inhibits apoptosis by sponging miR-498 to enhance LEF1 expression, forming a circ_0032463/miR-498/LEF1 regulatory axis. |
| Confidence score: |
0.8058 |