circRNA basic information
circBase ID: hsa_circ_0004808
Name: hsa_circ_USP48
Synonym: hsa_circRNA_100093
Host Gene: USP48
Genomic location(hg19): chr1:22047528-22048257:-
Genomic location(hg38): chr1:21721035-21721764:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: Acute ischemic stroke
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; plasma brain-derived exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Serves as a potential diagnostic biomarker for AIS and is positively correlated with NIHSS and mRS scores, indicating association with disease severity and progression.
Molecular mechanism: Predicted involvement in stroke-related signaling pathways based on GO and KEGG enrichment analysis.
Biological pathway or process:

MAPK (other); Hippo/YAP (other); Wnt/beta-catenin (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential biomarker for AIS with high specificity and sensitivity; AUC 0.8563; expression positively correlated with NIHSS and mRS scores.
Description:

hsa_circ_0004808 is an up-regulated plasma brain-derived exosomal circRNA in AIS. It was validated in clinical plasma-derived exosomes and showed diagnostic and disease severity associations.
Confidence score:

0.559
Other information
Title:

Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Published: 2024
PubMed ID: 38647743
Study type:

combined biological and clinical study
Data availability: article/Supplementary Material; raw and processed data are stored in the laboratory and are available upon request
Code availability: -