| Expression pattern: |
DN |
| Associated gene: |
SLC5A7 |
| Associated microRNA: |
miR-338-5p |
| Biological function: |
inhibits proliferation, migration and invasion; promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA (miRNA sponge): circFBXW4 binds miR-338-5p to relieve repression of SLC5A7 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis; Survival Analysis |
| Clinical significance: |
Low circFBXW4 expression in tumors was associated with a decreased overall survival (OS) time; circFBXW4 expression can effectively distinguish between CRC tissues and non-CRC tissues (AUC = 0.879). |
| Description: |
circFBXW4 is down-regulated in colorectal cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-338-5p, thereby relieving repression of SLC5A7 and inhibiting CRC cell proliferation, migration/invasion while promoting apoptosis, including suppression of xenograft tumor growth. |
| Confidence score: |
0.8888 |