| Expression pattern: |
UP |
| Associated gene: |
C‐E‐Cad, PI3K/AKT pathway, TGF‐beta/Smad pathway |
| Associated microRNA: |
- |
| Biological function: |
promotes GC cell proliferation, migration, EMT, tumor growth and peritoneal dissemination |
| Molecular mechanism: |
circRNA encodes protein (C‐E‐Cad); TGF‐beta/Smad increases circ‐E‐Cad RNA and C‐E‐Cad protein; protumor effects mediated by C‐E‐Cad via PI3K/AKT signaling |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); EMT (promotes); PI3K/AKT (promotes); TGF-beta/SMAD (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ‐E‐Cad might be a useful tumor marker in GC |
| Description: |
circ‐E‐Cad is up-regulated in gastric cancer tissues and cell lines and is mainly localized in the cytoplasm. Functional assays using circ‐E‐Cad knockdown/overexpression indicate it promotes malignant phenotypes, with effects mediated by its encoded protein C‐E‐Cad that activates PI3K/AKT and is induced by TGF‐beta/Smad signaling. |
| Confidence score: |
0.5098 |