circRNA basic information
circBase ID: -
Name: hsa_circ_CDYL
Synonym: circCDYL
Host Gene: CDYL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005350
MONDO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm / AAA
Disease DO ID:
 7693
Disease MeSH ID:
 D017544
Disease NCIt ID:
 -
Disease ICD11 ID:
 1154633768
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

abdominal aortic aneurysm tissue
Cell lines:

HUVEC-MYC/ID1/ID2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: MYC
Associated microRNA: -
Biological function: Associated with AAA severity (lower in ruptured AAA vs elective AAA).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Lower circCDYL levels in ruptured AAA (emergency surgery) compared with elective AAA (P = 0.046).
Description:

circCDYL is reduced in more severe AAA (ruptured vs elective) based on qRT-PCR in human aneurysm biopsies, suggesting potential utility as a marker of AAA disease severity. The study does not provide a specific molecular mechanism for circCDYL in AAA.
Confidence score:

0.2995
Other information
Title:

Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.

Journal: Cardiovascular research
Published: 2025
PubMed ID: 39901821
Study type:

combined biological and clinical study
Data availability: GSE210361; GSE280608
Code availability: -