| Expression pattern: |
DN |
| Associated gene: |
AKT, STAT3, RBM24 |
| Associated microRNA: |
hsa-miR-1207-5p, hsa-miR-4691-5p, hsa-miR-4763-3p, hsa-miR-6807-5p, hsa-miR-7160-5p |
| Biological function: |
May serve as an early diagnostic biomarker for POI and may affect follicle growth and development, ovarian granulosa cell differentiation and proliferation, oocyte maturation, inflammatory aging, and glucose metabolism. |
| Molecular mechanism: |
Predicted ceRNA mechanism as a miRNA sponge regulating miRNA-associated mRNAs and signaling pathways such as PI3K-AKT. |
| Biological pathway or process: |
PI3K/AKT (other); ceRNA regulation (other); proliferation (other); apoptosis (other); inflammation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Good diagnostic value for POI; AUC = 0.8041; potential biomarker for early diagnosis of POI. |
| Description: |
hsa_circRNA_403959 was significantly downregulated in plasma from POI patients and showed diagnostic potential with an AUC of 0.8041. Bioinformatics analysis suggested it may act as a miRNA sponge for five predicted miRNAs and may influence PI3K-AKT-related pathways, follicle development, granulosa cell proliferation/differentiation, inflammation, and glucose metabolism. |
| Confidence score: |
0.5047 |