circRNA basic information
circBase ID: hsa_circ_0006054
Name: hsa_circ_KIAA0355
Synonym: hsa_circ_006054
Host Gene: KIAA0355
Genomic location(hg19): chr19:34818325-34821252:+
Genomic location(hg38): chr19:34327420-34330347:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer lesions; adjacent normal-appearing tissues; breast cancer tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-5001-3p, hsa-miR-718, hsa-miR-4793-3p, hsa-miR-4524a-5p, hsa-miR-513a-5p
Biological function: May be involved in breast cancer carcinogenesis; proposed diagnostic biomarker.
Molecular mechanism: Predicted miRNA sequestration via MREs (miRNA sponge/ceRNA-like mechanism).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic performance assessed by ROC; in combination with hsa_circ_100219 and hsa_circ_406697 AUC = 0.82 (95% CI: 0.73-0.90).
Description:

hsa_circ_006054 (circBase: hsa_circ_0006054) is down-regulated in breast cancer tissues and was evaluated as a diagnostic biomarker, contributing to an AUC of 0.82 when combined with hsa_circ_100219 and hsa_circ_406697; its mechanistic role is suggested via predicted miRNA binding.
Confidence score:

0.5963
Other information
Title:

Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.

Journal: Oncotarget
Published: 2017
PubMed ID: 28484086
Study type:

combined biological and clinical study
Data availability: -
Code availability: -