| Expression pattern: |
UP |
| Associated gene: |
FGFR1, Argonaute 2 |
| Associated microRNA: |
miR-424-5p |
| Biological function: |
promotes lenvatinib resistance, cell viability/proliferation, migration, and tube formation (angiogenesis-related phenotype) in HCC cells |
| Molecular mechanism: |
acts as a ceRNA by sponging miR-424-5p to upregulate FGFR1, thereby promoting lenvatinib resistance |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); angiogenesis (promotes); drug resistance (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa-circ-0058046 (from BARD1) is upregulated in HCC cell lines and promotes lenvatinib resistance as well as proliferation/migration and pro-angiogenic activity. It mainly localizes to the cytoplasm and functions as a ceRNA sponge of miR-424-5p to increase FGFR1 expression, forming the hsa-circ-0058046/miR-424-5p/FGFR1 axis. |
| Confidence score: |
0.8491 |