circRNA basic information
circBase ID: hsa_circ_0001982
Name: hsa_circ_RNF111
Synonym: -
Host Gene: RNF111
Genomic location(hg19): chr15:59323002-59323901:+
Genomic location(hg38): chr15:59030803-59031702:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent normal tissues; tumor tissue; nontumor tissue
Cell lines:

HBL-100; MDA-MB-231; MCF-7; MDA-MB-468; MDA-MB-435s; HEK 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-143
Biological function: hsa_circ_0001982 promotes breast cancer cell proliferation and invasion and suppresses apoptosis; knockdown of hsa_circ_0001982 inhibits proliferation and invasion and induces apoptosis.
Molecular mechanism: hsa_circ_0001982 acts as a miRNA sponge for miR-143 in a ceRNA mechanism, decreasing miR-143 and thereby promoting breast cancer tumorigenesis and progression.
Biological pathway or process:

proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis
Clinical significance:

hsa_circ_0001982 may be useful as a prognostic biomarker and therapeutic target for breast cancer therapy.
Description:

hsa_circ_0001982 is up-regulated in breast cancer tissues and cell lines and was validated by qRT-PCR after microarray screening. Functionally, it promotes breast cancer cell proliferation and invasion while inhibiting apoptosis. Mechanistically, it acts as a miR-143 sponge in a ceRNA-like mechanism, and knockdown effects are rescued by miR-143 inhibition.
Confidence score:

0.7785
Other information
Title:

Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.

Journal: DNA and cell biology
Published: 2017
PubMed ID: 28933584
Study type:

combined biological and clinical study
Data availability: -
Code availability: -