| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-637, hsa-miR-2115-5p, hsa-miR-6881-3p |
| Biological function: |
hsa_circ_0037911 is up-regulated in whole blood of essential hypertension patients, may increase EH risk, may contribute to EH pathogenesis, correlates positively with serum creatinine, and may serve as a stable biomarker for early diagnosis of EH. |
| Molecular mechanism: |
Potential miRNA sponge mechanism involving miR-637; possible contribution to EH by changing serum creatinine concentration. |
| Biological pathway or process: |
ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher expression of hsa_circ_0037911 may be a risk factor and effective biomarker for early diagnosis of EH; AUC = 0.627, p = 0.002; expression correlates positively with serum creatinine. |
| Description: |
This case-control study found that hsa_circ_0037911 is significantly up-regulated in whole blood from essential hypertension patients and may increase EH risk. The circRNA showed diagnostic potential for EH and was positively correlated with serum creatinine. Mechanistically, the authors proposed that hsa_circ_0037911 may act as a miR-637 sponge and contribute to EH pathogenesis. |
| Confidence score: |
0.5963 |