| Expression pattern: |
UP |
| Associated gene: |
cyclin D1 / CCND1 |
| Associated microRNA: |
miR-153 |
| Biological function: |
promotes HCC cell proliferation and tumorigenesis; inhibits apoptosis; promotes cell cycle progression |
| Molecular mechanism: |
ceRNA mechanism: circ-PAN3 sponges miR-153 to upregulate cyclin D1 (CCND1) |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-PAN3 is increased in HCC clinical specimens and high circ-PAN3 is associated with poorer overall survival |
| Description: |
circ-PAN3 is up-regulated in HCC tissues/cell lines and its high level predicts poorer overall survival. Functionally, circ-PAN3 promotes HCC growth by acting as a ceRNA that sponges miR-153, thereby relieving repression of cyclin D1 (CCND1) and enhancing cell-cycle progression and proliferation. |
| Confidence score: |
0.7699 |