circRNA basic information
circBase ID: hsa_circ_0000375
Name: hsa_circ_IFFO1
Synonym: hsa_circRNA_101004
Host Gene: IFFO1
Genomic location(hg19): chr12:6657590-6657991:-
Genomic location(hg38): chr12:6548424-6548825:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumorous tissue samples; non-tumoruos mammary gland tissue samples; adjacent-non-tumour
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AHNAK, PPARG, CAV1, FGF2, EGR1, TNXB, FOS
Associated microRNA: miR-183-5p
Biological function: may act as a sponge for miR-183-5p; highlighted circRNA that may play an important role in BLBC
Molecular mechanism: predicted miRNA sponge (ceRNA) for miR-183-5p
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study predicts that hsa_circ_0000375 (alias hsa_circRNA_101004) is down-regulated in breast cancer and may sponge miR-183-5p. It participates in predicted circRNA-miRNA-mRNA regulatory modules (e.g., involving hub genes such as FGF2, EGR1, TNXB) and is suggested for further cellular functional investigation.
Confidence score:

0.1768
Other information
Title:

Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.

Journal: PloS one
Published: 2024
PubMed ID: 38635539
Study type:

bioinformatics study
Data availability: GSE101124; GSE182471
Code availability: -