| Expression pattern: |
UP |
| Associated gene: |
TRIB1, Cyclin D1, BCL-2, MMP2, AGO2 |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
Enhances docetaxel resistance in prostate cancer; promotes cell proliferation, migration and invasion; suppresses apoptosis; exosomal circSFMBT2 transfers docetaxel resistance to normal prostate cancer cells and promotes tumor resistance in vivo. |
| Molecular mechanism: |
Exosomal circSFMBT2 functions as a miR-136-5p sponge and positively regulates TRIB1, thereby enhancing docetaxel resistance of prostate cancer cells and tumors. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Exosomal circSFMBT2 was highly expressed in the serum exosomes of docetaxel-resistant prostate cancer patients and could act as an independent diagnostic target for distinguishing docetaxel-sensitive and docetaxel-resistant prostate cancer patients. |
| Description: |
circSFMBT2 is up-regulated in docetaxel-resistant prostate cancer cells and in serum exosomes from docetaxel-resistant prostate cancer patients. It is transferred via exosomes and promotes docetaxel resistance, proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circSFMBT2 sponges miR-136-5p to up-regulate TRIB1, and it shows potential diagnostic and therapeutic relevance for docetaxel-resistant prostate cancer. |
| Confidence score: |
0.8596 |