| Expression pattern: |
UP |
| Associated gene: |
PEAK1, Ago2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes tumor growth |
| Molecular mechanism: |
Exosomal circSATB2 acts as a sponge of miR-330-5p to upregulate PEAK1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model |
| Clinical significance: |
Exo‐circSATB2 might be an effective biomarker for lung cancer patients. |
| Description: |
circSATB2 is up-regulated in lung-cancer-cell-derived exosomes and can be transferred into recipient lung cancer cells. Exosomal circSATB2 promotes proliferation, migration, invasion, and in vivo tumor growth by sponging miR-330-5p to increase PEAK1 expression. |
| Confidence score: |
0.6001 |