circRNA basic information
circBase ID: hsa_circ_0001846
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: UBAP2
Genomic location(hg19): chr9:33944362-33956144:-
Genomic location(hg38): chr9:33944364-33956146:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer / PC
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PC tissues; adjacent nontumorous tissues
Cell lines:

PANC-1; AsPC-1; BxPC-3; Capan-1; SW-1990; HPDE; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: KRAS
Associated microRNA: miR-204-3p
Biological function: promotes proliferation; promotes migration; promotes invasion; promotes tumor growth in vivo
Molecular mechanism: Acts as a miRNA sponge for miR-204-3p to upregulate KRAS (post-transcriptional) expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model
Clinical significance:

hsa_circ_0001846 may be a potential biomarker for clinical diagnosis and treatment of PC.
Description:

hsa_circ_0001846 (UBAP2-derived) is up-regulated in pancreatic cancer tissues and cell lines and promotes proliferation, migration, invasion, and xenograft growth. Mechanistically, it functions as a ceRNA by sponging miR-204-3p, thereby relieving repression of KRAS and enhancing KRAS expression, suggesting biomarker potential in PC.
Confidence score:

0.7663
Other information
Title:

Circular RNA hsa_circ_0001846 facilitates the malignant behaviors of pancreatic cancer by sponging miR-204-3p and upregulating KRAS expression.

Journal: Cell death discovery
Published: 2023
PubMed ID: 38081815
Study type:

combined biological and clinical study
Data availability: The data generated or analyzed in the current study are available from the corresponding author upon reasonable request.
Code availability: -