circRNA basic information
circBase ID: hsa_circ_0026654
Name: -
Synonym: HSA_CIRC_0026654
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005229
MONDO name: bacterial infectious disease with sepsis
Disease details: sepsis
Disease DO ID:
 0040085
Disease MeSH ID:
 D016470
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: GSPT1, NPRL3
Associated microRNA: hsa-miR-873-3p, hsa-miR-4538, hsa-miR-3064-5p, hsa-miR-7156-3p, hsa-miR-4252, hsa-miR-5093, hsa-miR-518c-5p, hsa-miR-937-5p, hsa-miR-3929, hsa-miR-106b-3p, hsa-miR-5187-3p, hsa-miR-99b-3p, hsa-miR-6504-5p, hsa-miR-1295b-3p, hsa-miR-612, hsa-miR-4725-3p, hsa-miR-5192, hsa-miR-3153, hsa-miR-5197-5p, hsa-miR-6811-3p, hsa-miR-1293, hsa-miR-491-5p, hsa-miR-1304-5p, hsa-miR-4651, hsa-miR-520g-5p, hsa-miR-6812-5p
Biological function: May regulate sepsis prognosis via ceRNA regulation of immune response-related core genes (GSPT1/NPRL3).
Molecular mechanism: Predicted ceRNA mechanism: binds miRNAs to indirectly regulate GSPT1 and NPRL3.
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Part of a sepsis-related ceRNA network proposed to be closely related to prognosis and may serve as novel biomarkers.
Description:

HSA_CIRC_0026654 was identified from blood circRNA-seq as part of a predicted sepsis prognosis-related ceRNA network. It is hypothesized to sponge miRNAs and thereby indirectly regulate the core genes GSPT1 and NPRL3, linking it to immune-response processes and sepsis outcome.
Confidence score:

0.1768
Other information
Title:

Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.

Journal: Scientific reports
Published: 2025
PubMed ID: 39843498
Study type:

combined biological and clinical study
Data availability: CNP0002611
Code availability: -