circRNA basic information
circBase ID: hsa_circ_0002111
Name: hsa_circ_PSD3
Synonym: circPSD3 / Circular RNA PSD3
Host Gene: PSD3
Genomic location(hg19): chr8:18622958-18662408:-
Genomic location(hg38): chr8:18765448-18804898:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma / PTC
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tumor tissue; normal tissue
Cell lines:

IHH4; BCPAP; Nthy-ori-3-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RAP2A, BRAF
Associated microRNA: miR-526b
Biological function: promotes proliferation and cell growth; promotes migration and invasion; inhibits apoptosis; promotes tumor growth
Molecular mechanism: circPSD3 acts as a ceRNA to sponge miR-526b, thereby upregulating RAP2A; BRAF overexpression downregulates circPSD3 and RAP2A while upregulating miR-526b
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; divergent primers PCR; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

circPSD3 is up-regulated in papillary thyroid carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, and tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-526b to increase RAP2A expression, and BRAF overexpression suppresses this circPSD3/miR-526b/RAP2A axis.
Confidence score:

0.8355
Other information
Title:

BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression.

Journal: BMC molecular and cell biology
Published: 2025
PubMed ID: 39838328
Study type:

combined biological and clinical study
Data availability: GSE93522; 10.1186/s12860-024-00528-2
Code availability: -