| Expression pattern: |
UP |
| Associated gene: |
N-cadherin, vimentin, snail, E-cadherin |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes EMT-associated metastatic behavior. |
| Molecular mechanism: |
circRNA_0023642 modulates EMT signaling, with knockdown decreasing N-cadherin, vimentin and snail and increasing E-cadherin at mRNA and protein levels. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot |
| Clinical significance: |
May represent a potential diagnostic and therapeutic marker or molecular therapeutic target for gastric cancer. |
| Description: |
circRNA_0023642 is up-regulated in gastric cancer tissues and cell lines. It functions as a tumor-promoting circRNA by enhancing proliferation, migration, invasion and EMT while suppressing apoptosis. The study suggests it may be a potential diagnostic and therapeutic marker for gastric cancer. |
| Confidence score: |
0.5442 |