| Expression pattern: |
UP |
| Associated gene: |
PSMC2 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
Promotes CRC cell proliferation, colony formation, migration, EMT, tumor growth and lung metastasis, and inhibits apoptosis. |
| Molecular mechanism: |
ceRNA mechanism: Hsa_circ_0007718 acts as a sponge of miR-1299, reducing miR-1299-mediated inhibition of PSMC2 and promoting PSMC2 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); EMT (promotes); apoptosis (inhibits); metastasis (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Sanger Sequencing; RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; Microarray |
| Clinical significance: |
circ_0007718 might be a valuable candidate target for CRC therapy. |
| Description: |
Hsa_circ_0007718/circ_0007718 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC progression by sponging miR-1299 and increasing PSMC2 expression, thereby enhancing proliferation, migration, EMT, tumor growth and lung metastasis while suppressing apoptosis. The study suggests circ_0007718 may be a potential therapeutic target for CRC. |
| Confidence score: |
0.7938 |